The primary goal of our research is to assist pharmaceutical companies and other researchers in the enhancement of patient care, at an affordable price, through innovative drug-delivery technologies. To this end, our group offers a theory-guided approach that validates experimental data and provides a cost-effective way to test conditions in order to reduce side effects before introducing a new product to the market. Our secondary goal is to continue to develop efficient analytical models for investigating innovative ideas in the field that are currently not being explored because of monetary constraints.
The Simon group is not only assisting pharmaceutical industries in the production of better drug delivery systems. We are also enriching the educational experience for future scientists and engineers...the students enrolled in our high schools and universities.
Our group has an in-depth knowledge of drug behavior in polymer devices and skin permeation kinetics. A full understanding of the mechanisms governing controlled release is essential for developing customized transdermal drug-delivery devices for clinical applications, R & D innovation and commercialization.
The service that we provide, to the biomedical and pharmaceutical sectors, integrates:
. Clinical trial simulations
. State-of-the art design of experiment (DOE) methodologies
. Principles of transport phenomena
. Modern control theory
. Rigorous mathematical analysis
. Pharmacokinetics / Pharmacodynamic (PK/PD) data analysis

Through in-vitro experiments and computer simulations, our team has the unique ability to corroborate or refute proposed theories and anticipate design failures such as those that may occur in Phase III clinical trials.


Research Interests >>
The main areas of research interest are transdermal drug delivery, protein purification, process modeling and control.
Click here for a more-detailed description.

Software Tools >>
Software tools developed by the Simon group to assist in process analysis and simulation.  The codes, mainly written in Mathematica®, are instrumental in building Population Pharmacokinetic/Pharmacodynamic models and designing transdermal drug-delivery systems. For questions or request, please complete the request form.
Laboratory Projects >>
Hands-on activities are offered to help undergraduates become better process designers and ensure a smooth transition from theory to practice. Students will gain a working knowledge of governing engineering principles in order to fully comprehend and appreciate the industrial and technological relevance along with the scope of chemical engineering. For questions or request, please complete the request form.

Refereed Articles >>
Our list of publications includes topics discussing mathematical modeling, trends in applications of neural networks, aqueous two-phase separation and transdermal drug-delivery systems. For a copy of the full article, please complete the request form.
Presentations >>
Conference papers presented at various Chemical Engineering meetings, including AIChE, are listed. Topics include: "The use of mathematical modeling and simulation tools to study transdermal drug-delivery systems", Purification of beta-glucosidase by aqueous two-phase partitioning" and "Artificial neural networks for the prediction of recombinant tissue-type plasminogen activator partition coefficients".  Click here for a complete list. For more information on a particular presentation, please complete the request form

Book Contributions-Citations >>
This section contains summaries of book chapters, citations, and a list of books where acknowledgements are given. Click here for lists.
K-12 Related Activities >>
This section describes innovative hands-on activities related to science and engineering.  Here, K-12 teachers will find resources that will enrich their current curriculum and enhance student learining. Click here for details

Affiliations >> 
The Simon group is affiliated with several prestigious organizations. Click here for list.

Awards >>
Honors acknowledging our work are listed. Click here for details

Content Copyright © 2010  Laurent Simon, Ph.D.   Site Design Copyright © 2010 SABERLIGHT
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