Book Contributions



  1. Simon, L. (2013). Control of Biological and Drug-Delivery Systems for Chemical, Biomedical, and Pharmaceutical Engineering. John Wiley & Sons, Inc., Hoboken, New Jersey.

    "The book addresses issues and solves problems that dominate both fields (i.e., biological sciences and release devices.) Many of the textbooks written on this topic usually focus on specific topics (e.g., systems biology, control of fermentation processes), as a result, undergraduate chemical engineering students are not exposed to a range of diversified problems in biological sciences. This book builds on the new focus of providing problems in the biological area. In addition, unified theories and step-by-step problem solving procedures are provided. A unique feature of the book is the application of control theory to analyze controlled-release devices."

Book Review



  1. Simon, L. and Ospina, Juan (2015). Closed-form Solutions for Drug Transport through Controlled-Release Devices in Two and Three Dimensions. John Wiley & Sons, Inc., Hoboken, New Jersey.

"Provides solutions for two- and three-dimensional linear models of controlled-release systems

  • Real-world applications are taken from used to help illustrate the methods in Cartesian, cylindrical and spherical coordinate systems
  • Covers the modeling of drug-delivery systems and provides mathematical tools to evaluate and build controlled-release devices
  • Includes classical and analytical techniques to solve boundary-value problems involving two- and three-dimensional partial differential equations
  • Provides detailed examples, case studies and step-by-step analytical solutions to relevant problems using popular computational software"


Book Chapters

  1. Eikens, B., Karim, M. N. and Simon, L. (2001). Combining Neural Networks and first principle models for bioprocess modeling. In: Application of Neural Networks and other Learning Technologies in Process Engineering (I.M. Mujtaba and M.A. Hussain, Eds.). Imperial College Press.

    Computationally efficient methods, which combine physical process knowledge with unmeasured disturbances, are proposed to address the demand for accurate modeling, automation and regulation of bioprocesses. The applications of this methodology range from identification, simulation to optimization of pharmaceutical systems.
  2. Eikens, B., Karim, M. N. and Simon, L. (2001). Process identification with self-organizing networks. In: Application of Neural Networks and other Learning Technologies in Process Engineering (I.M. Mujtaba and M.A. Hussain, Eds.*). Imperial College Press.

    A technique to visualize and identify industrial processes is outlined to represent the different metabolic states encountered during baker's yeast fermentation. This tool has the ability to extract useful information and discover patterns in large data collections even when the process is complex and poorly understood.
    Application of Neural Networks and Other Learning Technologies in Process Engineering. Imperial College Press, London, 2001. The book summarizes the use of neural networks to solve industrially relevant problems such as modeling, identification, estimation, control, and optimization. Foreword to the book: ".this book contains contributions in the field of neural networks and learning technologies from experts in different parts of the globe."
  3. Simon, L. (2010). Distributed parameter estimation of dermal absorption of chemicals using a physiologically inspired boundary condition. In: Skin Anatomy and Physiology Research Developments (L. F. Bukowskiy, Ed.). Nova Publishers. Download this article.

    The proposed methodology helps answer a series of important questions concerning dermal exposure: How fast are chemicals absorbed through the cutaneous layers? When a chemical comes into contact with the skin, how long does it take the substance to enter the bloodstream? After a few minutes of exposure, how far into the skin has the compound penetrated? The approach adopted in this study can facilitate the development of efficient dermal risk assessment strategies.

    Skin Anatomy and Physiology Research Developments. Nova Science Publishers Inc, NY, 2009. "Skin anatomy refers to the structure of the skin, which consists of two principal parts: the outer, thinner portion which is called the epidermis and the inner, thicker portion which is known as the dermis. Alternatively, skin physiology is the subdivision of physiology which concerns the functions of the skin including the regulation of body temperature, protection, sensation, excretion, immunity, blood reservoir and the synthesis of Vitamin D. There are more than a thousand conditions that may affect the skin but some of the most common skin diseases include rashes, bacterial infections, fungal infections, parasitic infections, pigmentation disorders, tumors and cancers and skin diseases that result from trauma. This new book gathers the latest research from around the globe in this field."

  4. Kim, K.S. and Simon, L. (2011). Optimal Control of Heat-Assisted Transdermal Drug-Delivery Systems. In: Process Control: Problems, Techniques and Applications (S. P. Werther, Ed.). Nova Publishers.

    Innovative and dynamic techniques to help devise efficient drug-delivery systems, while decreasing production costs, are outlined. In the proposed environment, treatment strategies and effects of temperature exposure on conventional patches can be evaluated and appropriate corrective action taken. A control scheme is recommended to overcome shortcomings of existing technologies.

    Process Control: Problems, Techniques and Applications. Nova Science Publishers Inc, NY, 2011. "Process control is a statistics and engineering discipline that deals with architectures, mechanisms and algorithms for controlling the output of a specific process. This new book presents current research in the study of the problems, techniques and applications of process control. Topics discussed include the surface enhancements process of shot-peening; statistical process monitoring; data acquisition and signal processing of frequency response (FR) evaluation during plasma electrolytic surface treatments; the Markov chain approach for performance evaluation of control charts and proactive feed-forward process control."
  5. Simon, L. (2016). Controlled Release Technology, Pharmaceutical. In: Kirk-Othmer Encyclopedia of Chemical Technology. John Wiley & Sons, Inc.
  6. Simon, L. (2016). Analytical and numerical methods in determining the combined effects of iontophoresis and chemical penetration enhancers. In: Percutaneous Penetration Enhancers Physical Methods in Penetration Enhancement, 1st ed. (Dragicevic, Nina, Maibach, Howard I, Eds.). Springer.

    Percutaneous Penetration Enhancers Physical Methods in Penetration Enhancement. Springer, NY, 2017. "Percutaneous Penetration Enhancers in a mini-series format comprising five volumes, represents the most comprehensive reference on enhancement methods – both well established and recently introduced – in the field of dermal/transdermal drug delivery. In detail the broad range of both chemical and physical methods used to enhance the skin delivery of drugs is described. All aspects of drug delivery and measurement of penetration are covered, and the latest findings are provided on skin structure and function, mathematics in skin permeation, and modern analytical techniques adapted to assess and measure penetration. In offering a detailed description of the methods currently in use for penetration enhancement, this book will be of value for researchers, pharmaceutical scientists, practitioners, students and dermatological scientists or dermatologists."

  7. Pontrelli, G. and Simon L. (2017). The choice of a performance indicator of release in transdermal drug delivery systems. In: Biomedical Technology: Modeling, Experiments and Simulation (Lecture Notes in Applied and Computational Mechanics), 1st ed. 2018 Edition (Wriggers, Peter and  Lenarz, Thomas, Eds.). Springer.

    The choice of a performance indicator of release in transdermal drug delivery systems. Springer, NY, 2017. "This book provides an overview of new mathematical models, computational simulations and experimental tests in the field of biomedical technology, and covers a wide range of current research and challenges. The first part focuses on the virtual environment used to study biological systems at different scales and under multiphysics conditions. In turn, the second part is devoted to modeling and computational approaches in the field of cardiovascular medicine, e.g. simulation of turbulence in cardiovascular flow, modeling of artificial textile-reinforced heart valves, and new strategies for reducing the computational cost in the fluid-structure interaction modeling of hemodynamics. The book’s last three parts address experimental observations, numerical tests, computational simulations, and multiscale modeling approaches to dentistry, orthopedics and otology. Written by leading experts, the book reflects the remarkable advances that have been made in the field of medicine, the life sciences, engineering and computational mechanics over the past decade, and summarizes essential tools and methods (such as virtual prototyping of medical devices, advances in medical imaging, high-performance computing and new experimental test devices) to enhance medical decision-making processes and refine implant design. The contents build upon the International Conference on Biomedical Technology 2015 (ICTB 2015), the second ECCOMAS thematic conference on Biomedical Engineering, held in Hannover, Germany in October 2015."


Books where acknowledgements are given

  1. Belfiore, L.A. Transport Phenomena for Chemical Reactor Design. John Wiley & Sons, Inc., 2003.
  2. Smith, C.A. and Corripio, A. Principles and Practice of Automatic Process Control, 3rd ed. John Wiley & Sons, Inc., 2006.


Simon group citations in published books

  1. Rathbone, M., Senel, S. and Pather, I. (Eds.). Oral Mucosal Drug Delivery and Therapy (Advances in Delivery Science and Technology), 2015th ed. Springer, 2015.
  2. Pabby, A.K., Rizvi, S.S.H., Requena, A.M.S. (Eds.). Handbook of Membrane Separations: Chemical, Pharmaceutical, Food, and Biotechnological Applications, 2nd ed. CRC Press, 2015.

  3. Becker, S. and Kuznetsov, A. (Eds.). Heat Transfer and Fluid Flow in Biological Processes,1st ed.  Academic Press, 2015.

  4. Geris, L. (Ed.). Computational Modeling in Tissue Engineering. Springer, 2013.

  5. Sabu, A. and  Augustine, A. (Eds.). Prospects in Bioscience: Addressing the Issues. Springer, 2013.
  6. Musa, S.M. (Ed.). Computational Finite Element Methods in Nanotechnology. CRC Press, 2012.
  7. Undey, C., Low, D., Menezes, J.C. and Koch, M. (Eds.). PAT Applied in Biopharmaceutical Process Development And Manufacturing: An Enabling Tool for Quality-by-Design. CRC Press, 2011.
  8. Lebovka, L., Vorobiev, E. and Chemat, F. (Eds.). Enhancing Extraction Processes in the Food Industry. CRC Press, 2011.
  9. Ranade, V.V. and Cannon, J.B.  Drug Delivery Systems, Third Edition. CRC Press, 2011.
  10. Peinemann, K.-V. and Nunes, S.P. (Eds.) Membrane Technology: Volume 1: Membranes for Life Sciences. Wiley-VCH, 2007.
  11. Grassi, M., Grassi, G., Lapasin, R. and Colombo, I. Understanding Drug Release and Absorption Mechanisms: A Physical and Mathematical Approach. CRC Press, 2006.
  12. Dunn, S., Constantinides, A. and Moghe, P.V. Numerial Methods in Biomedical Engineering. Academic Press, 2005.
  13. Zhong, J.-J. and Scheper T. (Eds.). Biomanufacturing. Springer, 2004.
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